Transfus Med Hemother. 2014 Nov;41(6):403-4. doi: 10.1159/000369599. Epub 2014 Nov 14.
Responder individuality in red blood cell alloimmunization.
One may define human blood groups by two fundamental characteristics: i) determinants (antigens) are located on the outer surface of human red blood cells, and ii) these antigens are capable of provoking an immune reaction. The reaction may occur ‘naturally’, e.g., when the ABO blood group sys- tem forms isoagglutinins, or may be observed in an allogeneic setting, e.g., during pregnancy or after transfusion of poorly matched blood, in the process of alloimmunization. …